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Evodiamine, also known as Wu-Chu-Yu, is a type of chemical that is obtained by extracting it from the Evodia plant family.  Typically speaking, it is the Evodiae Fructus plant from which it is extracted.  As of yet, there have been no known studies performed on human subjects in order to test the efficacy of this ingredient.  However, there have been a number of studies* performed on rodents such as lab mice.

Research into Evodiamine

Within the animal studies that have been performed using Evodiamine in order to determine its benefits in helping to combat obesity, it has been indicated that the substance can help to reduce the intake of fat.  This suggests that there could be a possibility that, if it works in humans, it may be an effective ingredient in weight loss supplements.  However, there is still a long way to go in testing before that can be determined.

Animal studies can do nothing more than indicate whether or not further research is justified.  The reason is that even some of the types of animals that have reactions most similar to those of humans are still different.  No animal has an identical reaction to substances. Therefore, while animals are used to test the potential of a substance, no conclusions can ever be drawn about an ingredient from animal studies alone.

Traditional Chinese Medicine

Evodiamine has been used in Traditional Chinese Medicine for several centuries for its weight loss properties. Today, it can be purchased as a single ingredient supplement, or it can also be found as one of several substances that make up a larger formulation.  They can be purchased online at a wide variety of different vitamin merchants and health stores.

The studies that have been performed on animals using Evodiamine have suggested that it is the valliloids within the ingredient that are effective in helping to reduce the absorption of fat from consumed foods, as well as to boost the rate at which fat is burned from the body.  It is believed that this occurs as a result of thermogenic reactions, as it raises the body temperature.

Other Reasons This Ingredient is Used

Aside from being a diet pill ingredient, Evodiamine is also used for a range of other purposes.  It’s important to note that according to WebMD, this substance is used for a spectrum of other purposes.  That said, there is insufficient evidence to indicate that this ingredient is effective for any of these reasons.  These uses include:

  • Nausea
  • Vomiting
  • Diarrhea
  • Stomach pain
  • Lack of appetite
  • Headache
  • Heart failure
  • High blood pressure
  • Post-childbirth bleeding
  • Lack of menstruation
  • Stomach ulcers
  • Parasitic infection
  • Viral infection
  • GERD (gastroesophageal reflux disease)
  • Alzheimer’s disease
  • Fluid retention
  • Dysentery
  • Cancer

Before choosing this diet pill ingredient to help you with any of these – or other – conditions, it’s very important to speak with your doctor. There are a number of risks associated with this substance’s use. Moreover, as there is no proof that the ingredient will even work as hoped, these risks may mean that it could do far more harm than good.

Risks Associated with Evodiamine Use

The research has also indicated that Evodiamine can conflict with a number of different prescription drugs.  This makes it even more important that you speak with your doctor before beginning a weight loss program that includes a product that contains this substance.  Even if you aren’t taking any prescription medications, it is still important that you take this step, as it may also conflict with health conditions.

As there have been no human studies performed using Evodiamine, it is unknown how much would be required even if it was certain that this substance helped with weight loss in people.  Until a standardized, long-term controlled trial can be performed, the true efficacy and the correct dosage will remain unknown and it cannot be considered a true weight loss product, quite yet.

Who Shouldn’t Use this Ingredient?

Though there are many potential risks of using Evodiamine, there are some specific individuals who can be particularly harmed. According to WebMD, it is unsafe for pregnant or breastfeeding women to use this ingredient.  This ingredient contains chemicals that have proven to affect pregnant animals.  Though this hasn’t been tested on humans, it is not considered to be worth the risk after seeing the impact on animals. Doctors recommend staying on the safe side and not risking the health of an unborn or newborn child.

This ingredient can also slow blood clotting.  As a result, it is important not to use this ahead of or following surgery.  Using it would place a patient at risk of bleeding during surgery or afterward. If you’re already using this substance, your doctor will likely recommend that you stop using it at least 2 weeks ahead of a scheduled surgery. Be sure to tell a surgeon that you are using this substance if you need unscheduled surgery.

*  Yoshinori Kobayashi, Yumiko Nakano, Miho Kizaki, Kiyoko Hoshikuma, Yoshiharu Yokoo, Toshikazu Kamiya. Planta Medica.  “Capsaicin-Like Anti-Obese Activities of Evodiamine from Fruits of Evodia rutaecarpa, a Vanilloid Receptor Agonist”. December 16, 2000; 628-633. http://www.decatrim.com/downloads/evodiamine.pdf

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